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Tuesday, November 5, 2024

Examine Hyperlinks Synthetic Sweetener Erythritol to Blood Clots


Yesterday, a small new research out of the Cleveland Clinic’s Lerner Analysis Institute in contrast the consequences of the synthetic sweetener erythritol versus sugar and landed on grim outcomes—particularly, that erythritol elevated the chance of blood clots and coronary heart illness.

For those who’ve ever tried to chop again in your sugar consumption with zero-calorie swaps, you’ve almost definitely had erythritol. It’s a sugar alcohol usually used to sweeten up issues like baked items, ice cream, sodas, sweet, and even protein bars with out including further energy.

Erythritol’s security has been an ongoing debate amongst docs and customers. It’s beforehand been linked to a better danger of stroke and coronary heart assaults, however in keeping with the FDA, it’s GRAS (usually acknowledged as protected) to eat.

Right here, a heart specialist weighs in on the brand new analysis and breaks down the chance.

A better have a look at the research

The research, printed within the journal Arteriosclerosis, Thrombosis, and Vascular Biology, had a particularly restricted pattern measurement—solely 20 individuals. Some members got water sweetened with 30 grams of erythritol, whereas others drank water sweetened with 30 grams of standard sugar. Thirty minutes afterward, everybody had their blood drawn. The members who drank the erythritol-sweetened beverage confirmed excessive ranges of blood platelet exercise (clotting), however there was no change for the members who drank sugar water.

“Erythritol is poorly metabolized by the physique, which means that it’s arduous to your physique to eliminate it, particularly in case you eat it in massive portions,” says Nikki Bart, MD, a coronary heart failure and coronary heart transplant heart specialist on the Victor Chang Cardiac Analysis Institute. “There may be an rising sign right here that it will not be as protected as beforehand believed.”

However, Dr. Bart provides: “The outcomes must be taken with the caveat that the whole variety of individuals studied is small.” Nonetheless, this is not the primary research to hyperlink erythritol with problematic results. “The identical group printed a population-based research final 12 months linking increased ranges of erythritol to cardiovascular occasions in 4,000 individuals,” she notes.

Dr. Bart says given how restricted the research is, extra analysis linking erythritol to cardiovascular occasions is critical. It’s additionally necessary to notice that the research members got so much of erythritol in a single sitting (greater than you’d usually get from ingesting one zero-sugar soda or consuming one erythritol-sweetened protein bar), which doubtless affected the outcomes.

What does this imply for individuals who monitor their blood sugar and select zero-sugar choices?

Though extra analysis must be finished to attract any agency conclusions, it could be greatest to restrict erythritol and different synthetic sweeteners in your weight loss program, particularly in case you dwell with power situations like diabetes, hypertension, and coronary heart illness.

Generally, “sugar and sugar substitutes must be restricted and prevented the place attainable,” Dr. Bart says. “Sugar substitutes themselves have been linked to weight problems, diabetes, and different well being situations. Plus, they’re synthetic and might be pro-inflammatory.”

The most suitable choice to sweeten meals, she says, is vegetables and fruit, which have added dietary advantages.

What can individuals do to decrease their danger of blood clots?

Past limiting erythritol and different synthetic sweeteners, Dr. Bart says sustaining a wholesome weight is most necessary for lowering blood clot danger.

In line with the Mayo Clinic, blood clot danger may also be lowered by doing the next:

  • Keep away from sitting for lengthy intervals of time
  • Follow each day motion, even when it’s only a mild stroll
  • Keep hydrated
  • If in case you have hypertension, take steps to decrease it
  • Give up smoking

The underside line is, there’s so much we nonetheless don’t know concerning the physique’s response to erythritol. As a basic rule of thumb, although, complete, unprocessed meals like contemporary vegetables and fruit are undisputedly higher than something chemically made. However extra investigating must be finished to find out the long-term results of synthetic sweeteners on well being.


Nicely+Good articles reference scientific, dependable, latest, sturdy research to again up the knowledge we share. You may belief us alongside your wellness journey.


  1. Witkowski, Marco, et al. “Ingestion of the Non-Nutritive Sweetener Erythritol, however Not Glucose, Enhances Platelet Reactivity and Thrombosis Potential in Wholesome Volunteers.” Arteriosclerosis Thrombosis and Vascular Biology, 8 Aug. 2024, https://doi.org/10.1161/atvbaha.124.321019. Accessed 9 Aug. 2024.


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